Observations on brain phosphatases

Observations on the Acid Phosphatases of Euglena Gracilis

When a bleached strain of Euglena is maintained in a medium containing very low con centrations of phosphate, the acid phosphatase activity increases. The increase in acid phosphatase activity is prevented by Actinomycin D and by p-fluorophenylalanine (PFA), indicating that the increased activity is due to de novo synthesis of acid phosphatase. When phosphate is replenished, the acid phosphatas...

Pathological Observations on the Brain

Protein tyrosine phosphatases expressed in the developing rat brain.

Previous studies of the developing nervous system have shown that cell-cell and cell-matrix interactions are involved in a variety of processes such as the proliferation, migration, and differentiation of neurons. While many cell-surface molecules have been identified, the signal transduction mechanisms through which they modify cellular responses are poorly understood. Recent studies have desc...

The localization of some acid phosphatases in brain tissue.

The histological study of phosphatase distribution began when Gomori (1939) and Takamatsu (1939) independently published a technique for the demonstration of alkaline phosphatase in tissue sections. This method was extended to the localization of acid phosphatase under normal and pathological conditions (Gomori, 1941). Wolf, Kabat, and Newman (1943) studied the distribution of this enzyme with ...

The action of the phosphatases of human brain on lipid phosphate esters.

Much work, using both histochemical and standard biochemical techniques, has been carried out on the phosphatases of peripheral nerve. It is known that this tissue contains both alkaline (Landow, Kabat, and Newman, 1942) and acid phosphatases (Wolf, Kabat, and Newman, 1943), and the changes in the levels of these enzymes in nerves undergoing Wallerian degeneration following transection have bee...